Glycotech provides high-quality recombinant human selectins and anti-selectin antibodies for research in inflammation, metastasis, and cancer diagnostics. Our products are essential tools for studying cell adhesion mechanisms in various malignancies, including breast, colon, lung, and pancreatic cancers.
Recombinant human selectins for cell adhesion research
| Product Name | Product Number | Unit Size | Price* (USD) As of 9/15/08 |
|---|---|---|---|
| Human E-selectin IgG | 51-005 | 60 mg | $445 |
| Human P-selectin IgG | 51-006 | 50 mg | $445 |
| Human L-selectin IgG | 51-007 | 50 mg | $445 |
Monoclonal antibodies for E-selectin detection and blocking
| Product Name | Product Number | Unit Size | Price (USD) |
|---|---|---|---|
| Anti-E-selectin Isotype: IgG1 (7A9) | 11-002 | 200 µg | $350.00 |
E-selectin is a cell adhesion molecule expressed on activated endothelial cells that mediates the interaction of tumor cells with the vascular endothelium. This interaction is a critical step in the metastatic cascade, facilitating tumor cell extravasation and secondary site colonization.
Research has shown that elevated E-selectin levels correlate with poor prognosis in various cancers including breast, colon, and lung cancer. Targeting E-selectin-mediated adhesion represents a promising therapeutic strategy for preventing metastasis.
P-selectin is stored in platelet α-granules and Weibel-Palade bodies of endothelial cells, rapidly mobilized to the cell surface upon activation. It mediates platelet-leukocyte and endothelial-leukocyte interactions critical for thrombus formation and inflammatory responses.
L-selectin is constitutively expressed on leukocytes and facilitates lymphocyte homing to peripheral lymph nodes. Together, these selectins orchestrate the complex processes of immune surveillance, inflammation, and cancer progression.
Blocking selectin-mediated adhesion has emerged as a novel therapeutic approach to inhibit metastasis. Anti-selectin antibodies, selectin antagonists, and carbohydrate-based inhibitors are being developed to disrupt tumor cell-endothelial interactions.
Preclinical studies demonstrate that selectin inhibition reduces metastatic burden and improves survival in animal models. Glycotech's recombinant selectins and neutralizing antibodies provide essential tools for advancing this promising field of cancer research.
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High-quality monoclonal antibodies for cancer diagnostics and research
Our comprehensive panel of antibodies targets specific carbohydrate antigens expressed on various tumor cells. These antibodies are essential tools for immunohistochemistry, flow cytometry, and ELISA applications in cancer research and clinical diagnostics.
| Product Name | Tumor | Product Number | Unit Size | Price* (USD) |
|---|---|---|---|---|
| CA19-9 Isotype: IgG1 (GSLA-2) | Gastrointestinal and Pancreatic | 11-009 | 200 µg | $270.00 |
| DUPAN-2 Isotype: IgM (DUPAN-2) | Gastrointestinal and Pancreatic | 11-010 | 200 µg | $270.00 |
| Anti-GM3 Isotype: IgG3 (DH2) | Melanoma | 10-011 | 200 µg | $270.00 |
| Anti-Lex Isotype: IgM (BRA-4F1) | Leukemia | 10-008 | 200 µg | $270.00 |
| Anti-Extended Lex Isotype: IgG1 (GELF31) | Breast | 11-005 | 200 µg | $270.00 |
| Anti-Extended sialyl-Lex Isotype: IgM (FH6) | Ovarian | 11-007 | 200 µg | $270.00 |
| Anti-Ley Isotype: IgG2a (BR55) | Breast | 11-006 | 200 µg | $270.00 |
| Anti-Gb3 Isotype: IgM (1A4) | Lymphoma (B, Burkitt's) | 11-008 | 200 µg | $270.00 |
*Prices are for research use only. For bulk pricing, please contact us.
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